ubiquitin conjugating enzymes การใช้

• This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin.
• This protein belongs to the ubiquitin conjugating enzyme family and is one of the E2 enzymes.
• SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins.
• CUL4A protein is 759 amino acids long and forms an extended, rigid structure primarily consisting of E2 ubiquitin conjugating enzymes.
• RBX1 is a core component of Cullin-RING ubiquitin ligase ( CRL ) complexes and functions to recruit E2 ubiquitin conjugating enzymes.
• The interaction of this protein with UBE2N / UBC13, and UBE2V1 / UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein.
• UBC9 is a ubiquitin conjugating enzyme whose proteins associates with MITF . Although hUBC9 is known to act preferentially with SENTRIN / SUMO1, an in vitro analysis demonstrated greater actual association with MITF . hUBC9 is a critical regulator of melanocyte differentiation.
• UBE2Z spans 246 amino acids, 150 of which encode a conserved 16 18 kDa ubiquitin conjugating enzyme E2 domain ( UBC domain ) that is located at the enzyme s substrate binding, which is characteristic of a class II E2 ubiquitin conjugating enzyme.
• UBE2Z spans 246 amino acids, 150 of which encode a conserved 16 18 kDa ubiquitin conjugating enzyme E2 domain ( UBC domain ) that is located at the enzyme s substrate binding, which is characteristic of a class II E2 ubiquitin conjugating enzyme.
• "' Ubiquitin conjugating enzyme E2 Z ( UBE2Z ) "', also known as UBA6-specific E2 enzyme 1 ( USE1 ), is an enzyme that in humans is encoded by the " UBE2Z " gene on proteolysis.
• The ER membrane anchored RING finger containing ubiquitin ligases Hrd1 and Doa10 are the major mediators of substrate ubiquitination during ERAD . The tail anchored membrane protein Ubc6 as well as Ubc1 and the Cue1 dependent membrane bound Ubc7 are the ubiquitin conjugating enzymes involved in ERAD.